Assessment of myeloperoxidase (Mpo) gene polymorphism in cervical cancer

Background/Aim: Cervical cancer (CC) is the most common gynecological malignancy in women. In spite of a variety treatment protocols, it necessary to carefully investigate all factors that play role pathogenesis these tumors which may have mortal progression. this context, our study we aimed assess myeloperoxidase (MPO) gene polymorphism, an important inflammatory enzyme, among cervix cases. Methods: cross-sectional study, 79 cases diagnosed as cervical carcinoma between 1992-2012 included. The without archival paraffin blocks and clinical follow-ups are excluded. All slides with tumor involvement reviewed ones demonstrate tumor’s characteristics determined. After block determination 3 sections 10-micron thickness obtained from MPO polymorphism was shown using acil restriction endonuclease enzyme fragment length (RFLP) method after polymerase chain reaction (PCR). histopathological parameters including stage type, lymph node metastasis, ovary endometrium involvement, recurrence late metastasis compared genotype chi-square Fisher’s exact test. Results: mean age 51.3 (10.9) years. Of cases, 29 (36.7%) had AG (adenine-guanine) 50 (633%) GG (guanine-guanine) genotypes. Only identified statistically difference assessed histopathologic (P=0.015). When assessed, there no mortality (P=0.622). Conclusion: thought progressive regressive development due response host. Within framework, assessing one foundation stones MPO, more endometrial for genotype. We believe significance will be encountered broad case series.